Recent advances in technology have supported multimedia experiences to become more interactive and immersive. Traditional multimedia devices aimed to capture user attention through content rich visuals presented on two-dimensional displays. However, in recent times, emerging head mounted display (HMD) technologies such as Virtual reality (VR) and augmented reality (AR) HMDs aim to captivate users through the delivery of 360 visuals, immersive audio, and environments within which the user can interact. In this research, an immersive multimedia speech and language disorder assessment application was developed and novel user perceptual quality evaluations across three different platforms were undertaken. The speech and language disorder assessment application gave context to this research and directed it in terms of how to design an ecologically valid health application. The user perceptual quality evaluations were carried out on tablet, AR, and VR platforms under the auspices of the quality of experience (QoE) framework. In this context, the novel contribution of the PhD work presented in this thesis reflects efforts to design, develop, and understand user QoE of an immersive multimedia speech and language disorder assessment application. The research involved a comprehensive and rigorous comparison of three different platforms (AR, Tablet, and VR) by exploring the use of: explicit (subjective ratings); implicit (eg physiological, and psychophysiological); and objective measures of user performance and interaction. The comparison required a novel QoE assessment methodology and evaluation which facilitated not only …